Short-Acting Testosterone: More Physiologic?

Are Long-Acting Opioids More Effective Than Short-Acting Opioids for Chronic Pain?

A new study calls into question the view that extended-release/long-acting (ER/LA) opioids are more effictive than immediate-release/short-acting (IR/SA) formulations for the management of chronic pain.1 The acceptance of the purported benefits of ER/LA opioids is understandable for patients whose pain is continuous and fairly constant over the course of the day. As an accompanying editorial to...

LONG-ACTING CONTRACEPTIVE AGENTS: TESTOSTERONE ESTERS OF CYCLOALKYLCARBOXYLIC ACIDS

The synthesis of twenty five esters of testosterone (17β -hydroxyandrost- 4-en-3-one) is described. All esters are derivatives of cycloalkycarboxylic acids. Some of the esters possess α- , β -and/or & - substitution in the ester side-chain. The work was undertaken in order to evaluate long-acting male antifertility effect of such esters. Most of the compounds, especially compound No.1, wer...

Long-acting testosterone undecanoate for parenteral testosterone therapy

More than eight years' hands-on experience with the novel long-acting parenteral testosterone undecanoate.

Testosterone (T) as a compound for treatment of T deficiency has been available for almost 70 years, but the pharmaceutical formulations have been less than ideal. Traditionally, injectable T esters have been used for treatment, but they generate supranormal T levels shortly after the 2-3 weekly injection interval. T levels then decline very rapidly, becoming subnormal during the days preceding...

Testosterone implants in women: pharmacological dosing for a physiologic effect.

OBJECTIVES The objectives of this study were to determine therapeutic serum testosterone (T) levels/ranges and inter-individual variance in women treated with subcutaneous T implants. STUDY DESIGN In study group 1, T levels were measured at two separate time intervals in pre- and post-menopausal women treated with subcutaneous T for symptoms of androgen deficiency: (i) four weeks after pellet...